While Duff Beer comes in several varieties, it is revealed on a Duff Brewery tour in “Duffless” that regular Duff, Duff Light, and Duff Dry are the same beer, although Homer and Barney apparently remain oblivious to the fact. A tasting room also contained several varieties that Barney stated they hadn’t tried yet, including Raspberry Duff, Lady Duff, and Tartar Control Duff. In “Homer’s Odyssey”, Duff is described as “The beer that makes the days fly by”.

Matt Groening has stated that he will not license the Duff trademark to brew an actual beer, over concern that it would encourage children to drink. However, there have been a few notable cases of individual companies and persons who have used the term “Duff Beer” with varying success.